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Cannabis in Treating Depression, Anxiety and PTSD syndromes

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Anxiety and PTSD

Cannabis. The sound of it triggers widely different reactions from people across the world. This is primarily a consequence of the idea of it being a ‘drug’ coupled with the long ongoing debate over the legalisation of it, in different parts of the world. Although many countries have legalised it, it will not be wrong to say that they have not accepted it. The driving cause behind it has been the fact that, while intensive research has been conducted to draw the ills of the cannabis plant, there has been a dissipated approach towards gathering evidence about the benefits of it. Hence, in a country like India, cannabis otherwise known as weed, marijuana, ganja, etc can be easily passed as a ‘sign of danger’. Any person associated with it, in any manner, either needs to face stern action or needs to be kept away from. In order to combat this mentality and establish a balanced opinion about the plant, it is paramount that the general public be made aware of the working of cannabis, as a drug, in one’s body.

Cannabis Constituents


Medicinal Cannabis, a much lesser known term in the country, is made up of over 400 chemical compounds ranging from cannabinoids, terpenoids, etc. to fatty acids. The research into medicinal cannabis, still being at a nascent stage, has distinctly identified only two of the 61 cannabinoids, delta-9 tetrahydro-cannabinol or THC and Cannabidiol or CBD, respectively. THC, recognised for its intoxicating effects, has been proven to act on CB1 receptors, that are present throughout the body. CB1 receptor is one of the many cannabinoid receptors that is most sufficiently present in the brain. It’s effect is thus, felt significantly in the brain as THC, being an active constituent of cannabis, binds to the CB1 receptors in the brain and activates them, giving the much hyped ‘high’ to individuals who consume it. Contrary to the effects produced by THC, CBD, the only other constituent of cannabis that has been studied, is known to contain no pyshcoactive element in it, whatsoever. Hence, does not produce any intoxicating effects.

How Cannabis works in the body


While CB1 receptors are mustered in the brain and the central nervous system of the body, CB2 receptors are spread throughout the body including our heart, kidney, liver, blood vessels, etc. CB1 and CB2 receptors, the only classified receptors among the many other receptors present in the body, form the core of the Human Endocannabinoid System(ECS). Cannabinoids are known for their brisk interaction with this system. Hence, it is necessary to have a brief discussion and understanding about this system.

The Human Endocannabinoid System


The Human Endocannabinoid System, is a complex and crucial system in the body, responsible for maintaining biological balance of the body, when things go awry. ECS, literally, produces molecular cannabinoids endogenously in the body, as and when required, to sustain the body in its ideal conditions. This phenomenon of sustaining the body in its ideal conditions is known as homeostasis. ECS and homeostasis go hand-in-hand, making ECS, an integral part of the body.

CBD and it’s significance


Shifting our focus back to CBD, which is widely recognised for it’s therapeutic potential, apart from having no intoxicating effects, it is also proven to counter the effects of THC on the body. Unlike THC, CBD’s binding affinity to the CB1 receptors, is abysmally low. This is where a line can be drawn between THC and CBD when it comes to these constituents affecting the behavioral mannerisms of an individual, who is a frequent consumer of cannabis. While THC’s psychoactive effects include euphoria, relaxation when taken in lesser dosage, it also leads to anxiety, short term memory impairment when the dosage intake is high and consistent. CBD due to it’s poor binding affinity with CB1 receptors produces the opposite effect of decreasing anxiety and short term memory impairment. In today’s world, where anxiety and depression lead the charts with maximum number of people of suffering from it, cannabis, otherwise considered a stigma, it being useful in contributing towards the cure of anxiety and depression, has come out as a significant revelation.

In addition to this, there has also been scientific proof, discovered recently, about how lower dosage of THC can even lead to inhibition of anxiety. This is because, varying dosage of THC has differring effects on the neural activity of the brain and the nervous system, due to its variation in the capacity of bonding with the receptors.

Cannabis for Therapeutic Purposes


Such discoveries have been potential reasons for encouraging researchers across the world to delve deeper into the use of CPT, i.e, Cannabis for Therapeutic Purposes. Studies have found that the use of cannabis does not contribute to any individual indulging either in self-harm or in harm to others. Experiences in medical practice have substantiated that Dronabinol, a synthetic form of THC, has been effective in uplifting moods and developing a sense of well-being in individuals, when appropriate dosage is taken regularly. When it comes to the use of cannabis as a treatment for PTSD, i.e, Post Traumatic Stress Disorder, evidence mainly consists of success stories of patients. Clinical trials and scientific research is yet to be done in this regard.


Keynote


While Canadian government offers remuneration to its military officers for cannabis use pertaining to treatment of PTSD, U.S has started begetting ways for combined CBT and medication treatment for anxiety and depression patients. Other countries like Czech Republic, Spain, Uruguay, Netherlands have not only initiated their journey but have also recognised important results about the potential of medicinal cannabis. It’s high time, India breaks out of its conventional and conformist mindset and takes steps towards discarding the label of stigma, off cannabis.

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Hemp in India

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Hemp In India

Hemp, also known as industrial cannabis, has a long standing relationship with India and it’s culture. From it’s mention in the ancient religious texts, the Vedas as one of the five sacred plants to it being the front runner in the legalisation movement till date, hemp has been a part of India’s history. One of the two primary species of cannabis- cannabis indica, traces the origin of it’s name to India. Hemp as a raw material can contribute in the production of 25,000 products, ranging from products in industries such as gas and oil, to textiles and bodycare.

With Himalayas and the state of Uttarakhand being a treasure trove of hemp and all other states in India betting on the quality of their respective hemp production, India is home to some of the best quality of hemp in the world. However, hemp in India is still not officially legal due to the stigmatization attached to the crop. The controversies revolving around it linking it to the controversial amount of THC and marijuana, have hindered its business growth, more than one can imagine.

Hemp in Indian states

Uttarakhand being the first Indian state to have secured the rights for industrial hemp cultivation in 2018, it was a marked victory in this long drawn battle of hemp legalisation. The state government of Uttarakhand also granted license to Indian Industrial Hemp Assosciation(IIHA) to establish and operate their non-profit organisation. Apart from the products that can be made using hemp, cultivation of industrial hemp is extremely eco friendly. It requires very little to no use of pesticides. Since India lies in the tropical region, temperature and environmental conditions of India are also suitable for hemp cultivation.

While the direct benefits of hemp cultivation will be extended towards poor famers, who otherwise had to spend a huge amount of money for the timely cultivation of the crop, the GDP share of agriculture sector will also see a rise. Hemp, being a stronger and more absorbent fibre than cotton, sustainable agriculture of hemp will take India a long way, who in fact is looking to diversify from its conventional methods of farming.

Followed by Uttarakhand, are states like Madhya Pradesh and Manipur, where ministers have come out stating the need for legalisation of cultivation of hemp. While Madhya Pradesh’s law minister had already made an announcement about allowing the cultivation of hemp for medical and industrial purposes, there has been no progress made following it. Chief Minister of Manipur on the other hand has taken a firm decision regarding this issue and mentioned that it is very important for the state to utilise it’s natural resources efficiently and use the revenue generated for the development of the state.

Growth map of hemp market

With the first cannabis clinic of India, Vedi Herbals, opening in Bangalore in February, 2020, established by an Odisha based startup HempCann Solutions, it is a win for the cannabis legalisation movement. With Vedi Herbals having been granted a pan India license, it remains to be seen how this would pave way for expansion of hemp market in India.

Apart from the newbie HempCann solutions, there are other companies such as Bombay Hemp Company(BoHeCo), Indian Hemp and Co., B.E.Hemp, that have somehow managed to sustain the idea of medicinal and industrial hemp thriving in India.

HempStreet, established in 2019, is another newbie in the hemp market and is India’s first research to retail venture in the ayurvedic cannabis sector. Having received a funding of 1 million dollars from US based pharmatech, Pharmacon Holdings and Romain Barberis, HempStreet primarily focuses on medicinal hemp and aims to source hemp based painkillers in the hemp market. These facts paint a picture of that of how hemp in India, as a market would experience a notable shift in the coming years. 

Final Word

Despite of being illegal, a study conducted by All India Institute of Medical Sciences(AIIMS) in 2019 reported that there are 7.2 million consumers of industrial hemp within that year. This implies that hemp in India, already has an established consumer base. The need of the hour, is to lend wings to this miraculously healing and industrial crop, such that it’s benefits reach the less privileged and provide relief to those who need it.  

References

https://inc42.com/startups/hempstreet-bets-high-on-indias-medical-cannabis-potential-with-eye-on-blockchain/

https://www.entrepreneur.com/article/306962

https://www.iihaindia.org/about-ihemp/

https://www.bingedaily.in/article/marijuana-2020-the-possibilities-for-india

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Does CBD help or hinder sleep

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Does Cannabis Help or Hinder Sleep

Who doesn’t like a good night sleep? It is quite difficult for one to function without sleep in today’s stressful, fast- paced world. However, these are the very factors that often lead to people not getting enough sleep. For conditions like sleep apnea, insomnia, narcolepsy, etc. people are often prescribed over the counter medicines for instant relief. These medications; however, may have serious side effects on the patients. Due to this, many consumers try to explore medical cannabis as a potential sleep aid. Through this article, we would discuss whether Cannabis helps or hinders sleep.

CBD and sleep

CBD has become popular in the medical field, wherein, individuals are consuming it to treat a number of ailments, including insomnia. Due to this sudden increase in its popularity, a number of ongoing clinical and preclinical studies are trying to find whether CBD can help with various disorders. However, there are limited studies are centered on CBD and sleep.

A recent Consumer Reports survey that was conducted on CBD reported that 10% of its respondents were consuming CBD as a sleep aid. Most of them assured that it worked, however, the evidence is anecdotal. It is important for controlled studies to be conducted in order to gain some conclusive evidence about whether CBD really induces sleep.

High CBD strains often contain a terpene called myrcene. This terpene is said to have sedating effects. Therefore, myrcene has been used as a sleep aid since centuries. However, myrcene is found in several other plants apart from cannabis, such as hops. Therefore, researchers are unsure whether it is the myrcene in the CBD rich strains that helps people sleep or whether it is CBD itself. However, it can be noted that CBD is not generally consumed in a vaporized form, and therefore, does not contain much myrcene.

Another research conducted in 2017 extensive literature review titled: Cannabis, Cannabinoids, and Sleep: a Review of the Literature, studies the effects of CBD in conjunction with THC on sleep. It concluded that both can be used as sleep aids.

Consuming multiple cannabinoids at the same time might have mixed effects. THC has certain sedative-like effects on individuals. It has multiple properties that help individuals sleep, for instance, it helps people feel comfortable while being able to remain still. This is called catalepsy. CBD, on the other hand, does not alter the consciousness of individuals like THC. As a result, it is difficult to ascertain whether CBD alone can act as a sleep aid.

Dosage

A Preliminary study showed that CBD doses ranging from 75 to 300 mg helped patients sleep. In one particular case, high dose CBD also helped a PTSD patient. Since CBD does not have any psychedelic properties, it is safe to consume higher doses of it for optimum effects. A study held in 2018 administered doses of 1500, 3000, and 6000 mg to healthy subjects for six days. It concluded that CBD was safe to be consumed at higher dosages.

Conclusion

Through the aforementioned argument, it can be assessed whether CBD helps or hinders sleep. It should be noted that CBD’s effect on sleep requires a great deal of further research. Despite the fact that CBD seems to help patients sleep, its effects are subjective and differ from person to person. It is a great alternative for those who wish to use a product with no side-effects. Additionally, CBD is worth exploring for those who want to avail the benefit of marijuana without the psychedelic effects of THC. If you have trouble sleeping, you can consult your medical practitioner before using CBD for your condition. We strongly advise against self-medication.

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Hemp seed: An Ayurvedic medication

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Hemp seed: An Ayurvedic medication

With most of the chaos around hemp being caluminous, have you ever tried to look beyond it? Well, if you haven’t, it’s your time now. Hemp, as a whole plant, is a gift of nature, that has been evaded for way too long now. First discovered in the foothills of Himalayas in India, hemp, also finds its mention in the vedas as one of the five sacred plants ‘bhang’. Since then, the only issue that has thwarted the reach of hemp in each household in the country, is the stigma that has latched onto it.

Weeding out this stigma would not be very hard, once its potential users are made aware of its benefits- be it on the health front or on the industrial front. Each part of hemp plant– seeds, stalk, fibre, flower- have incontestable benefits, which when unveiled would place it as a frontrunner for raw material, in almost every sector.

This article however, would primarily talk about hemp seeds, which lie at the heart of the plant. Hemp seeds in India have been a part of Ayurvedic medication for the good.

Let us explore how their role are interwoven and shed light upon Hemp seed: An Ayurvedic medication.

Hemp seeds and nutrition

Hemp seeds, having been a part of India’s history, is a legacy of its own, handed down over to the humankind by the Himalayas. Since then, from being used in the ropes to tie cattle to being used to cure ailments, hemp seeds have done it all.

Hemp is essentially a part of one of the eight clinical domains of Ayurveda, i.e, the Rasayana Tantra( the knowledge of rejuvenation). A great source of protein, the nutritional properties of hemp seeds have made this possible and thus, it is highly valued by the human society.  The nutritional properties are as follows:

  • Improve immunity
  • Smoothens muscle functions
  • Anti-inflammatory
  • Boosts hormonal balance
  • Aids cardiovascular health
  • Helps in weight loss

In addition to the above properties, hemp oil obtained from hemp seeds, also called hemp seeds oil, is rich in Vitamin E, Vitamin D, Vitamine B1 and Vitamine B2, essential fatty acids as well as minerals. Apart from being very effective as a medicinal aid, hemp seeds oil also works wonders for skin and hair.

In the circle of Ayurvedic medication, hemp seeds and hemp seeds oil are particularly beneficial for Vata(meaning, space and air) dosha and also helps in balancing the Pita(meaning, fire and water) dosha. These doshas, according to Ayurvedic teaching, are the different types of energies that lay the foundation of life. Hemp seeds, as Ayurveda believes, despite having no THC content, has tamasic(sedative) qualities, which make you feel rejuvenated, by releasing serotonin and inducing deep sleep. Hemp seeds are also nutritionally more efficient than flax and chia seeds. Hemp seeds, an ayurvedic medication, has more to it than nutritional properties.

Hemp seeds in industry

Industrial hemp, has contributed in an conducive way to diverse sectors such as- fabric or clothing, construction, bodycare products, biofuel, paper, amongst many others. Since agriculture of hemp plants requires

  • Negligible amount of pesticides
  • Is capable of returning the essential nutrients to the soil
  • Can be harvested within 3 months
  • Consumes minimal amount of water,

It is extremely environment friendly. As the top producer of biomass in the world and competent of producing the strongest fibre, hemp seeds is extremely popular in the industrial world.   

Ways of intake of hemp seeds

Few common ways being:

  • Blend to make hemp seed milk
  • Eat raw as snack
  • Powder it to consume as condiment
  • Sprinkle on top of dishes
  • Make a smoothie by adding few more ingredients

You can also innovate different ways of inculcating it into your diet and adding flavor. You can also choose from different type of hemp seeds available depending on the flavor, although the natural flavour is mostly nutty in taste.

Bottomline

Hemp seeds: an Ayurvedic medication, could also cause mild diarrhoea or inhibit platelet formation. Like everything in this world, these are amongst the very few side effects of hemp seeds. Hence, it is advisable to consult your doctor before beginning to consume it on a regular basis or including it in your medication. Although when it comes products constituting hemp seeds oil for hair and skin available in the market, those are scientifically proven. Thus, do not give a second thought before purchasing those products because what’s better than nature’s gifts for well being of humankind.

References

https://medium.com/@ministryofhemp/what-are-the-benefits-of-hemp-seeds-584fc352257c

https://bohecolife.com/blogs/hemp-health-nutrition/at-the-heart-of-hemp-all-you-need-to-know-about-hemp-seed-nutrition

https://somatheeram.org/en/vata/

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